Ionization profile monitors (IPMs) are installed in the Fermilab Booster, Main Injector and Tevatron. They are used routinely for injection matching measurements. For emittance measurements the IPMs have played a secondary role to the Flying Wires, with the exception of the Booster (where it is the only profile diagnostics). As Fermilab is refocusing its attention on the intensity frontier, non-intercepting diagnostics such as IPMs are expected to become even more important. This paper gives an overview of the operational use of IPMs for emittance and injection matching measurements at Fermilab, and summarizes the future plans.